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Impact of Norepinephrine and Selective β1-Adrenoceptor Blockers on the Growth of Retinal Tissue Explants

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We studied the effect of norepinephrine and selective β1-adrenoceptor blockers on the growth of retinal tissue explants from 10-12-day-old chicken embryos in organotypic culture. The test drugs produced a dose-dependent effect on cell proliferation. Norepinephrine (10−12 M) and atenolol (10−4 M) are shown to signifi cantly stimulate explant growth. Combined treatment with norepinephrine (10−12 M) and atenolol (10−4 M) results in cumulation of their stimulatory effects. The results suggest that the retina-stimulating effect of norepinephrine is based on its interactions with other types of adrenoceptors.

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Authors and Affiliations

  1. Department of Experimental Physiology and Pharmacology, V. A. Almazov Federal Heart, Blood, and Endocrinology Center, Federal Agency for High-Technological Medical Care, St. Petersburg, Russia

    E. V. Lopatina & V. A. Tsyrline

  2. Laboratory for Physiology of Excitable Membranes, I. P. Pavlov Institute of Physiology, St. Petersburg, Russia

    E. V. Lopatina & V. A. Penniyaynen

Authors
  1. E. V. Lopatina
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  2. V. A. Penniyaynen
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  3. V. A. Tsyrline
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Correspondence to E. V. Lopatina.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 153, No. 1, pp. 56-58, January, 2012

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Lopatina, E.V., Penniyaynen, V.A. & Tsyrline, V.A. Impact of Norepinephrine and Selective β1-Adrenoceptor Blockers on the Growth of Retinal Tissue Explants. Bull Exp Biol Med 153, 48–50 (2012). https://doi.org/10.1007/s10517-012-1639-2

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  • DOI: https://doi.org/10.1007/s10517-012-1639-2

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