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Effects of Heparin on Synaptic Activity in the Hemorrhagic Stroke Model in Vitro

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We studied the ability of heparin to modify synaptic activity on the original stroke model in vitro. Cultured slices of the brain slices from hypertensive rats were treated with the auto blood clot. Administration of heparin (2 mg/ml) before autoblood treatment had a protective effect on ionotropic glutamatergic and GABAergic receptors, whose activity was inhibited by the blood.

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Authors and Affiliations

  1. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    A. A. Mokrushin & L. I. Pavlinova

Authors
  1. A. A. Mokrushin
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  2. L. I. Pavlinova
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Correspondence to L. I. Pavlinova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 623-626, December, 2011

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Mokrushin, A.A., Pavlinova, L.I. Effects of Heparin on Synaptic Activity in the Hemorrhagic Stroke Model in Vitro . Bull Exp Biol Med 152, 684–687 (2012). https://doi.org/10.1007/s10517-012-1606-y

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  • DOI: https://doi.org/10.1007/s10517-012-1606-y

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