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Antifibrotic and Anti-Inflammatory Activity of a Neuroleptic Drug on the Model of Pulmonary Fibrosis

  • GENERAL PATHOLOGY AND PATHOPHYSIOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of course treatment with neuroleptic haloperidol on the inflammatory response and state of the connective tissue in the lungs of C57Bl/6 mice was studied on the model of toxic pulmonary fibrosis induced by intratracheal administration of bleomycin. This neuroleptic decreased the inflammatory response and reduced the growth of the connective tissue in the lungs. The anti-infl ammatory effect of haloperidol is related to a decrease in activity of bone marrow hemopoietic stem cells and committed hemopoietic precursors. The antifibrotic effect of this drug is associated with inhibition of mesenchymal precursor cells.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, E. G. Skurikhin, T. V. Andreeva, O. V. Pershina, L. A. Ermolaeva, E. S. Khmelevskaya, V. A. Krupin, A. M. Reztsova & I. E. Stepanova

Authors
  1. A. M. Dygai
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  2. E. G. Skurikhin
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  3. T. V. Andreeva
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  4. O. V. Pershina
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  5. L. A. Ermolaeva
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  6. E. S. Khmelevskaya
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  7. V. A. Krupin
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  8. A. M. Reztsova
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  9. I. E. Stepanova
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Corresponding author

Correspondence to O. V. Pershina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 618-622, December, 2011

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Dygai, A.M., Skurikhin, E.G., Andreeva, T.V. et al. Antifibrotic and Anti-Inflammatory Activity of a Neuroleptic Drug on the Model of Pulmonary Fibrosis. Bull Exp Biol Med 152, 679–683 (2012). https://doi.org/10.1007/s10517-012-1605-z

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  • DOI: https://doi.org/10.1007/s10517-012-1605-z

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