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Involvement of P2Y receptors in myocardial contractile activity of rats during postnatal ontogeny

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We studied the effect of uridine 5’-triphosphate in concentrations of 10−10−10−10 M on myocardial contractile activity in 7-100-day-old rats. Analysis of isometric contraction of myocardial strips showed that uridine 5’-triphosphate reduced the strength of myocardial contraction in rats of all age groups. In 21- and 100-day-old rat pups, exogenous uridine 5’-triphosphate produced a stronger inhibitory effect than in 7-day-old animals. The negative inotropic effect of UTP was abolished under conditions of P2Y4 purinoceptor blockade with reagent blue-2. These data indicate that the effect of UTP on the myocardium is realized via P2Y4 purinoceptors.

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Authors and Affiliations

  1. Department of Human Anatomy and Physiology, Tatar State Humanitarian-and-Training University, Kazan, Russia

    T. A. Anikina, I. N. Anisimova & F. G. Sitdikov

Authors
  1. T. A. Anikina
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  2. I. N. Anisimova
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  3. F. G. Sitdikov
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Corresponding authors

Correspondence to T. A. Anikina or I. N. Anisimova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 12, pp. 611–613, December, 2011

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Anikina, T.A., Anisimova, I.N. & Sitdikov, F.G. Involvement of P2Y receptors in myocardial contractile activity of rats during postnatal ontogeny. Bull Exp Biol Med 152, 672–674 (2012). https://doi.org/10.1007/s10517-012-1603-1

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  • DOI: https://doi.org/10.1007/s10517-012-1603-1

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