Patients with infectious viral or toxic cirrhosis of the liver participated in complex clinical pathomorphological and molecular-genetic study aimed at the search for markers of predisposition to accelerated liver fibrosis, in which the xenobiotic biotransformation system is involved. The results demonstrate association between CYP2D6 (1846 G/A) genotype and rapid cirrhosis development and indicate the necessity of studying the mechanisms underlying this association.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 11, pp. 568-571, November, 2011
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Nepomnyashchikh, D.L., Vavilin, V.A., Aidagulova, S.V. et al. Cytochrome P450 2D6 Polymorphism Is a Molecular Genetic Marker of Liver Cirrhosis Progression. Bull Exp Biol Med 152, 633–636 (2012). https://doi.org/10.1007/s10517-012-1595-x
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DOI: https://doi.org/10.1007/s10517-012-1595-x