Activities of prolyl endopeptidase and dipeptidyl peptidase IV in the frontal cortex, hypothalamus, nucleus accumbens, striatum, and hippocampus were measured in rats with the experimental anxious-depressive syndrome induced by treatment with a dipeptidyl peptidase IV inhibitor during the early postnatal period (days 5-18). Prolyl endopeptidase activity was elevated in the frontal cortex, hypothalamus, and nucleus accumbens. Increased activity of dipeptidyl peptidase IV was observed in the hypothalamus and striatum. Norepinephrine/serotonin reuptake inhibitor, imipramine, and noncompetitive prolyl endopeptidase inhibitor, benzyloxycarbonyl-methionyl-2(S)-cyanopyrrolidine, were shown to abolish depression-like behavior of animals in the forced swimming test. These compounds had a normalizing effect on activities of prolyl endopeptidase and dipeptidyl peptidase IV in brain structures of rats.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
N. A. Krupina, N. N. Zolotov, N. G. Bogdanova, et al., Byull. Eksp. Biol. Med., 142, No. 11, 497–499 (2006).
N. A. Krupina, E. Yu. Kushnareva, N. N. Khlebnikova, et al., Ibid., 147, No. 3, 254–260 (2009).
N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, Ibid., 120, No. 8, 160–164 (1995).
N. A. Krupina, I. N. Orlova, and G. N. Kryzhanovskii, Zh. Vyssh. Nervn. Deyat., 49, No. 5, 865–876 (1999).
E. Yu. Kushnareva, N. A. Krupina, N. N. Khlebnikova, et al., Byull. Eksp. Biol. Med., 151, No. 6, 619–623 (2011).
N. N. Khlebnikova, N. A. Krupina, I. N. Orlova, et al., Ibid., 147, No. 1, 27–31 (2009).
L. F. Barrett, K. A. Lindquist, E. Bliss-Moreau, et al., Perspect. Psychol. Sci., 2, No. 3, 297–311 (2007).
J. R. Kapoor and C. D. Sladek, Am. J. Physiol. Regul. Integr. Comp. Physiol., 280, No. 1, 69–78 (2001).
J. E. Knuuttila, P. Törönén, and E. Castren, Neurochem. Res., 6, 1235–1244 (2004).
M. Maes and S. Bonaccorso, Acta Psychiatr. Scand., 109, No. 2, 126–131 (2004).
M. Maes, F. Goossens, S. Scharpé, et al., Psychiatry Res., 58, No. 3, 217–225 (1995).
P. T. Männistö, P. Tuomainen, O. Kutepova, et al., Pharmacol. Biochem. Behav., 49, No. 1, 33–40 (1994).
G. Racagni and M. Popoli, Dialogues Clin. Neurosci., 10, No. 4, 385–400 (2008).
I. Schulz, B. Gerhartz, A. Neubauer, et al., Eur. J. Biochem., 269, No. 23, 5813–5820 (2002).
S. R. Sesack and A. A. Grace, Neuropsychopharmacology, 35, No. 1, 27–47 (2010).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 10, pp. 387-391, October, 2011
Rights and permissions
About this article
Cite this article
Khlebnikova, N.N., Krupina, N.A., Kushnareva, E.Y. et al. Effect of Imipramine and Prolyl Endopeptidase Inhibitor Benzyloxycarbonyl-Methionyl-2(S)-Cyanopyrrolidine on Activity of Proline-Specific Peptidases in the Brain of Rats with Experimental Anxious-Depressive Syndrome. Bull Exp Biol Med 152, 409–412 (2012). https://doi.org/10.1007/s10517-012-1540-z
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-012-1540-z