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Vascular Endothelial Growth Factor and Its Receptors in the Placenta of Women with Type 1 Diabetes Mellitus

  • MORPHOLOGY AND PATHOMORPHOLOGY
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Bulletin of Experimental Biology and Medicine Aims and scope

We performed a morphological study of placentas from women with type 1 diabetes mellitus receiving insulin therapy (insulin pump). Expression of vascular endothelial growth factor (VEGF) and its receptors (VEGFR-1, VEGFR-2, VEGFR-3) was demonstrated by immunohistochemical methods. Processes of branched angiogenesis predominated in the placentas from women with type 1 diabetes mellitus. Immunohistochemical study revealed more intensive reaction of VEGF and its receptors in syncytiotrophoblast and capillary endothelium of terminal villi.

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Authors and Affiliations

  1. V. I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia

    E. A. Dubova, K. A. Pavlov, R. M. Esayan, E. I. Degtyareva, A. I. Shchegolev & G. T. Sukhikh

  2. Institute of Diabetes, Endocrinology Research Center, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia

    R. M. Esayan & M. V. Shestakova

Authors
  1. E. A. Dubova
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  2. K. A. Pavlov
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  3. R. M. Esayan
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  4. E. I. Degtyareva
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  5. M. V. Shestakova
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  6. A. I. Shchegolev
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  7. G. T. Sukhikh
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Corresponding author

Correspondence to E. A. Dubova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 9, pp. 337-341, September, 2011

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Dubova, E.A., Pavlov, K.A., Esayan, R.M. et al. Vascular Endothelial Growth Factor and Its Receptors in the Placenta of Women with Type 1 Diabetes Mellitus. Bull Exp Biol Med 152, 367–370 (2012). https://doi.org/10.1007/s10517-012-1530-1

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  • DOI: https://doi.org/10.1007/s10517-012-1530-1

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