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Effect of hypoxia on the state of tissues in samr1 and samp1 mice with various rates of aging

  • Biogerontology
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Bulletin of Experimental Biology and Medicine Aims and scope

Senescence-accelerated SAMP1 mice were more sensitive to the negative effect of hypobaric hypoxia than SAMR1 mice (control). Low-temperature EPR spectroscopy showed that high sensitivity of SAMP1 mice is related to the increased concentration of methemoglobin in the blood leading to hemic hypoxia. Proton magnetic relaxation study showed that the exposure of SAMP1 mice to hypoxia can cause cerebral edema.

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia

    M. G. Makletsova & S. L. Stvolinsky

  2. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, Russia

    G. T. Rihireva & V. L. Sharygin

Authors
  1. M. G. Makletsova
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  2. G. T. Rihireva
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  3. S. L. Stvolinsky
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  4. V. L. Sharygin
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Corresponding author

Correspondence to M. G. Makletsova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 9, pp. 330-333, September, 2011

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Makletsova, M.G., Rihireva, G.T., Stvolinsky, S.L. et al. Effect of hypoxia on the state of tissues in samr1 and samp1 mice with various rates of aging. Bull Exp Biol Med 152, 360–363 (2012). https://doi.org/10.1007/s10517-012-1528-8

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  • DOI: https://doi.org/10.1007/s10517-012-1528-8

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