The spectrum of alternatively spliced IL-4 and IL-6 gene mRNA was studied in peripheral blood mononuclears from healthy donors and in human fetal tissues. It was found that the expression of alternatively spliced IL-4 and IL-6 gene mRNA in fetal tissues is tissue specific and that hemopoiesis- and immunopoiesis-related tissues differ by the amount of IL-4 and IL-4δ2 mRNA. An mRNA variant IL-4alt3 carrying partial exon 3 deletion was for the first time identified in human mononuclear cells.
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S. V. Sennikov, A. N. Silkov, and V. A. Kozlov, Med. Immunol., No. 3, 389–400 (2001).
A. N. Silkov, V. A. Gavrilenko, V. V. Denisova, et al., Byull. Eksp. Biol. Med., 143, No. 1, 78–80 (2007).
S. P. Atamas, J. Choi, V. V. Yurovsky, and B. White, J. Immunol., 156, No. 2, 435–441 (1996).
M. P. Bihl, K. Heinimann, J. J. Rüdiger, et al., Am. J. Respir. Cell Mol. Biol., 27, No. 1, 48–56 (2002).
F. Sanger, S. Niclein, and A. R. Coulson, Proc. Natl. Acad. Sci. USA., 74, 5463–5467 (1977).
E. T. Wang, R. Sandberg, S. Luo, et al., Nature,. 456, 470–476 (2008).
O. P. Yatsenko, M. L. Filipenko, E. A. Khrapov, et al., Cytokine, 28, Nos. 4–5, 190–196 (2004).
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 9, pp. 298–301, September, 2011
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Yatsenko, O.P., Silkov, A.N., Khrapov, E.A. et al. Tissue-Specific Expression of Splice Variants of Human IL-4 and IL-6 Gene mRNA. Bull Exp Biol Med 152, 329–332 (2012). https://doi.org/10.1007/s10517-012-1520-3
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DOI: https://doi.org/10.1007/s10517-012-1520-3