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Mechanisms of Action of Ladasten: Activation of Gene Expression for Neurotrophins and Mitogen-Activated Kinases

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effects of single treatment with ladasten (50 mg/kg) on the content of effector kinases of the mitogen-activated cascade (ERK1/ERK2), pERK1/ERK2 activity (Thr202/Tyr204), and expression of genes for neurotrophic factors BDND and NGF in the striatum, hypothalamus, and hippocampus of rats.

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Correspondence to M. Kh. Salimgareeva.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 9, pp. 281–285, September, 2011

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Salimgareeva, M.K., Yamidanov, R.S., Vakhitova, Y.V. et al. Mechanisms of Action of Ladasten: Activation of Gene Expression for Neurotrophins and Mitogen-Activated Kinases. Bull Exp Biol Med 152, 313–317 (2012).

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