Experimental mutagenic effect of acrylamide on thyroid gland cells was studied by an extended micronucleus test. Acrylamide in doses corresponding to 0.004-0.1 LD50 increased the incidence of thyroid follicular cells (A-cells) with micronuclei and other karyological parameters in exposed rats after hemithyroidectomy. This cytogenetic effect allows regarding acrylamide as a mutagen for the thyroid gland and as a carcinogen for this organ.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 238-240, August, 2011
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Altaeva, A.A., Sycheva, L.P. & Belyaeva, N.N. Mutagenic Activity of Acrylamide in the Rat Thyroid Cells under Conditions of a Subacute Experiment. Bull Exp Biol Med 152, 275–277 (2011). https://doi.org/10.1007/s10517-011-1506-6
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DOI: https://doi.org/10.1007/s10517-011-1506-6