The effects of various alginate forms on the development of transplanted tumors in mice and efficiency of cytostatic therapy were studied. High-molecular-weight Ca and Na alginates, acid-soluble hydrolysate, and sodium alginate fraction inhibited the growth of Ehrlich adenocarcinoma. The use of acid-insoluble sodium alginate in chemotherapy protocol improved the treatment efficiency. All alginate forms inhibited metastasizing of Lewis pulmonary carcinoma; in combination with cyclophosphamide they potentiated its antimetastatic effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 191-196, August, 2011
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Razina, T.G., Rybalkina, O.Y., Lopatina, K.A. et al. Comparative Evaluation of the Efficiency of Various Alginate Forms under Conditions of an Oncological Experiment. Bull Exp Biol Med 152, 231–235 (2011). https://doi.org/10.1007/s10517-011-1496-4
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DOI: https://doi.org/10.1007/s10517-011-1496-4