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Insulin-like growth factors 1 and 2 regulate expression of β-casein in vitro in mouse mammary epithelial cells

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We studied the role of insulin-like growth factors 1 and 2 (IGF-1 and IGF-2) in functional differentiation of HC11 mouse mammary gland cells. It was found that both IGF-1 and IGF-2 activate the expression of milk protein β-casein in the presence of prolactin and hydrocortisone. It was found that β-casein expression is accompanied by cyclin D1 coexpression.

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Authors and Affiliations

  1. Institute of Carcinogenesis, N. N. Blokhin Rassian Oncological Research Center, Russian Academy of Medical Sciences, Moscow, Russia

    S. S. Shushanov

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  1. S. S. Shushanov
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Correspondence to S. S. Shushanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 162–165, August, 2011.

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Shushanov, S.S. Insulin-like growth factors 1 and 2 regulate expression of β-casein in vitro in mouse mammary epithelial cells. Bull Exp Biol Med 152, 202–205 (2011). https://doi.org/10.1007/s10517-011-1488-4

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  • DOI: https://doi.org/10.1007/s10517-011-1488-4

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