We studied the effect of inhibition of norepinephrine reuptake during the reperfusion period on the size of infarction zone after focal myocardial ischemia and under conditions of ischemic postconditioning. In groups 1 and 2, 30-min occlusion of the left coronary artery followed by 120-min reperfusion was performed. In groups 3 and 4, ischemia was followed by ischemic postconditioning (six 10-sec occlusions alternating with 10-sec reperfusions). Ringer solution (1 ml, groups 1 and 3) and desipramine (0.8 mg/kg, groups 2 and 4) were injected intravenously at the beginning of reperfusion. The area of myocardial infarction in group 1 was 32.0 ± 3.1% of the area of the risk zone; in groups 2, 3, and 4 the corresponding value was 46.1 ± 3.4% (p = 0.006), 22.2 ± 2.6% (p = 0.028), and 50.3 ± 3.1% (p = 0.018), respectively. It was shown that inhibition of norepinephrine reuptake in the early reperfusion period after ischemia increased myocardial injury and abolished the protective effect of ischemic postconditioning.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 152–154, August, 2011.
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Naumenko, S.E., Latysheva, T.V. & Gilinsky, M.A. Ischemic postconditioning and size of myocardial infarction during inhibition of norepinephrine reuptake. Bull Exp Biol Med 152, 192–194 (2011). https://doi.org/10.1007/s10517-011-1485-7
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DOI: https://doi.org/10.1007/s10517-011-1485-7