Tetrapeptide Pro-Gly-Pro-Leu in vitro effectively inhibited platelet aggregation over the entire range of studied concentrations (10−12–10−3 M). In concentrations of 10−9–10−3 M it exhibits fibrinolytic activity and in concentrations of 10−5–10−3 M has anticoagulant properties. Under in vivo conditions the analyzed tetrapeptide in a dose of 1 mg/kg increased anticoagulant, total and fibrin depolymerizating activities and increased activity of plasminogen activator. Intravenous administration produced more pronounced anticoagulant effect and leads to a greater increase in activity of plasminogen activator than intranasal administration. Tetrapeptide Pro-Gly-Pro-Leu also exerts antithrombotic effect. Preliminary repeated intranasal administration of the peptide before blood clot formation reduces the weight of fresh fibrin clots.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 144–147, August, 2011.
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Obergan, T.Y., Rochev, D.L. & Lyapina, L.A. Effects of peptide Pro-Gly-Pro-Leu under conditions of normal hemostasis and thrombus formation in rats. Bull Exp Biol Med 152, 184–187 (2011). https://doi.org/10.1007/s10517-011-1483-9
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DOI: https://doi.org/10.1007/s10517-011-1483-9