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Exenatide enhances kaliuresis under conditions of hyperkalemia

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Experiments on Wistar rats showed that exenatide (0.015–0.5 nmol per 100 g body weight) somewhat increased renal excretion of potassium from 7 ± 1 to 16 ± 1 μmol/h/100 g body weight (p < 0.05) in animals with normal serum concentration of glucose (4.6 ± 0.4 mM) and potassium (4.3 ± 0.1 mM). Exenatide dramatically enhanced excretion of potassium under conditions of hyperkalemia (11.4 ± 0.4 mM) produced by intraperitoneal injection of 1.25% KCl solution (5 ml per 100 g body weight). During the fi rst postinjection hour, potassium excretion increased 2-fold and attained 97 ± 11 μmol/h/100 g body weight in comparison with potassium load alone (47 ± 9 μmol/h/100 g body weight, p < 0.05). The data attest to a possible role of peptide regulators in normalization of potassium balance via renal mechanisms.

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Authors and Affiliations

  1. I. M. Sechenov Institute of Evolution Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia

    A. S. Marina, A. V. Kutina & Yu. V. Natochin

Authors
  1. A. S. Marina
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  2. A. V. Kutina
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  3. Yu. V. Natochin
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Correspondence to Yu. V. Natochin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 152, No. 8, pp. 137–139, August 2011.

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Marina, A.S., Kutina, A.V. & Natochin, Y.V. Exenatide enhances kaliuresis under conditions of hyperkalemia. Bull Exp Biol Med 152, 177–179 (2011). https://doi.org/10.1007/s10517-011-1481-y

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  • DOI: https://doi.org/10.1007/s10517-011-1481-y

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