Mutagenic activity of gold nanoparticles of different sizes were studied by micronucleus assay. Karyological analysis was performed and the count of micronucleoli in interphase bone marrow polychromatic erythrocytes in white outbred rats was determined. The animals orally received gold nanoparticles 16 and 55 nm in diameter and gold nanoshells 160 nm in diameter once a day for 7 days in a dose of 0.25 mg gold/kg. To ensure stability and biocompatibility, the surface of nanoparticles was functionalized with polyethylene glycol molecules. There were no signifi cant differences in the number of micronucleoli in comparison with the control group, which suggests that gold nanoparticles of the specifi ed size administered orally in the specifi ed doses do not exhibit mutagenic activity.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 677–680, June, 2011
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Jumagazieva, D.S., Maslyakova, G.N., Suleymanova, L.V. et al. Mutagenic Effect of Gold Nanoparticles in the Micronucleus Assay. Bull Exp Biol Med 151, 731–733 (2011). https://doi.org/10.1007/s10517-011-1427-4
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DOI: https://doi.org/10.1007/s10517-011-1427-4