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Role of Hydrogen Sulfide in the Regulation of Cell Apoptosis

  • Immunology and Microbiology
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Bulletin of Experimental Biology and Medicine Aims and scope

We studied the effect of a gas transmitter hydrogen sulfide (H2S) on the realization of apoptosis in Jurkat cells and mononuclear leukocytes from healthy donors. Treatment with H2S donor NaHS was accompanied by a dose-dependent intensification of cell death via apoptosis and necrosis. T-cell leukemia cells were more sensitive to H2S than mononuclear leukocytes from healthy donors. H2S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.

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Authors and Affiliations

  1. Siberian State Medical University, Russian Ministry of Health Care and Social Development, Tomsk, Russia

    N. V. Ryazantseva, V. V. Novitsky, E. G. Starikova, L. A. Kleptsova, V. D. Jakushina & E. V. Kaigorodova

Authors
  1. N. V. Ryazantseva
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  2. V. V. Novitsky
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  3. E. G. Starikova
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  4. L. A. Kleptsova
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  5. V. D. Jakushina
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  6. E. V. Kaigorodova
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Corresponding author

Correspondence to E. G. Starikova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 646–649, June, 2011

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Ryazantseva, N.V., Novitsky, V.V., Starikova, E.G. et al. Role of Hydrogen Sulfide in the Regulation of Cell Apoptosis. Bull Exp Biol Med 151, 702–704 (2011). https://doi.org/10.1007/s10517-011-1420-y

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  • DOI: https://doi.org/10.1007/s10517-011-1420-y

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