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Biological Activity of Some Derivatives of β-Cyclodextrin

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Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

New compounds of β-cyclodextrin containing covalently bound (conjugated) residues of acetylsalicylic and 1-(4-isobutylphenyl)-propionic acids were synthesized in the reaction of chlorides of the corresponding acids with β-cyclodextrin. We studied antiplatelet and antiphlogistic properties of these substances. It was shown that new compounds are comparable and in some cases are superior to the reference drugs acetylsalicylic acid and ibuprofen by anti-inflammatory and antiaggregant activities.

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References

  1. S. Glantz, Biomedical Statistics, Moscow (1994).

  2. G. I. Kurochkina, N. A. Kudryavtseva, M. K. Grachev, et al., Zhurn. Obsch. Khim., 77, No. 3, 477–484 (2007).

    Google Scholar 

  3. S. S. Liberman, S. N. Kutchak, E. A. Rudzit, et al., Farmakol. i Toksikol., 35, No. 3, 333–334 (1972).

    CAS  Google Scholar 

  4. M. D. Mashkovsky, Pharmaceuticals (Manual for Physicians) [in Russian], Moscow (2005).

  5. M. E. Davis and M. E. Brewster, Nature Rev. Drug Discovery, No. 3, 1023–1035 (2004).

  6. Cyclodextrins and Their Complexes. Chemistry, Analytical Methods, Applications, Ed. H. Dodziuk, Weinheim (2006).

  7. F. Hirayama, M. Kamada, H. Yano, et al., J. Incl. Phenom., 44, 159–161 (2002).

    Article  CAS  Google Scholar 

  8. K. Minami, F. Hirayama, and K. Uekama, J. Pharm. Sci., 87, No. 6, 715–720 (1998).

    Article  PubMed  CAS  Google Scholar 

  9. K. Uekama, F. Hirayama, and T. Irie, Chem. Rev. 98, No. 5, 2045–2076 (1998).

    Article  PubMed  CAS  Google Scholar 

  10. K. Uekama, K. Minami, and F. Hirayama, J. Med. Chem., 40, No. 17, 2755–2761 (1997).

    Article  PubMed  CAS  Google Scholar 

  11. H. Yano H, F. Hirayama, M. Kamada, et al., J. Control Release, 79, No. 1–3, 103–112 (2002).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Amur State Medical Academy, Blagoveshchensk, Russia

    T. A. Batalova, V. A. Dorovskich, M. L. Plastinin & A. A. Sergievich

  2. Moscow State Pedagogical University, Moscow, Russia

    G. I. Kurochkina & M. K. Grachev

Authors
  1. T. A. Batalova
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  2. V. A. Dorovskich
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  3. G. I. Kurochkina
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  4. M. K. Grachev
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  5. M. L. Plastinin
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  6. A. A. Sergievich
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Corresponding author

Correspondence to T. A. Batalova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 642–645, June, 2011

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Batalova, T.A., Dorovskich, V.A., Kurochkina, G.I. et al. Biological Activity of Some Derivatives of β-Cyclodextrin. Bull Exp Biol Med 151, 698–701 (2011). https://doi.org/10.1007/s10517-011-1419-4

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  • DOI: https://doi.org/10.1007/s10517-011-1419-4

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