Skip to main content
SpringerLink
Log in

Albendazole and Colchicine Modulate LPS-Induced Secretion of Inflammatory Mediators by Liver Macrophages

  • Pharmacology and Toxicology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Colchicine and albendazole inhibited LPS-induced secretion of TNF-α and NO in a primary culture of rat Kupffer cells. Both agents potentiated the stimulating effect of this toxin on prostaglandin E2 secretion. The amount of prostaglandin D2 remained unchanged under these conditions.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. J. Chen, Z. Wang, C. M. Li, et al., J. Med. Chem., 53, No. 20, 7414–7427 (2010).

    Article  PubMed  CAS  Google Scholar 

  2. L. C. Green, D. A. Wagner, J. Glogowsky, et al., Anal. Biochem., 126, No. 1, 131–138 (1982).

    Article  PubMed  CAS  Google Scholar 

  3. F. L. Henriquez, P. R. Igram, S. P. Muench, et al., Antimicrob. Agents Chemother., 52, No. 3, 1133–1135 (2008).

    Article  PubMed  CAS  Google Scholar 

  4. S. Knopp, K. A. Mohammed, B. Speich, et al., Clin. Infect. Dis., 51, No. 12, 1420–1428 (2010).

    Article  PubMed  CAS  Google Scholar 

  5. J. J. Li, S. H. Lee, D. K. Kim, et al., Am. J. Physiol. Renal Physiol., 297, No. 1, F200-F209 (2009).

    Article  PubMed  CAS  Google Scholar 

  6. Z. Li, G. S. Davis, C. Mohr, et al., Immunobiology, 195, Nos. 4–5, 624–639 (1996).

    PubMed  CAS  Google Scholar 

  7. M. H. Pourgholami, K. T. Wangoo, and D. L. Morris, Anticancer Res., 28, No. 5A, 2775–2779 (2008).

    PubMed  CAS  Google Scholar 

  8. P. Schemmer, N. Enomoto, B. U. Bradford, et al., Am. J. Physiol. Gastrointest. Liver Physiol., 280, No. 6, G1076-G1082 (2001).

    PubMed  CAS  Google Scholar 

  9. G. L. Su, Ibid., 283, No. 2, G256-G265 (2002).

    CAS  Google Scholar 

  10. A. V. Victorov, E. R. Abril, C. E. Hamlin, et al., Cells of the Hepatic Sinusoid, Eds. E. Wisse, D. L. Knook, and R. S. Mc-Cuskey, Leiden (1991), Vol. 3, pp. 449–452.

  11. A. V. Victorov and J. B. Hoek, Biochim. Biophys. Res. Commun., 215, No. 2, 691–697 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Research Institute of Epidemiology, Laboratory for Molecular Mechanisms of Infection, Moscow, Russia

    A. V. Viktorov & V. A. Yurkiv

Authors
  1. A. V. Viktorov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. A. Yurkiv
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A. V. Viktorov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 6, pp. 627–629, June, 2011

Rights and permissions

Reprints and permissions

About this article

Cite this article

Viktorov, A.V., Yurkiv, V.A. Albendazole and Colchicine Modulate LPS-Induced Secretion of Inflammatory Mediators by Liver Macrophages. Bull Exp Biol Med 151, 683–685 (2011). https://doi.org/10.1007/s10517-011-1415-8

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10517-011-1415-8

Key Words

Search

Navigation