Structure of the tracheal wall of male Wistar rats was studied by histological methods on days 1, 3, and 7 after experimental hemorrhagic stroke. Signs of impaired microcirculation and lymphatic drainage were revealed at all stages of the experiment. In the acute phase of stroke (day 1), these disturbances lead to destruction of epithelial cells and their extensive desquamation, edema of the submucosa, and hemorrhages in the tracheal wall. On days 3 and 7 of the experiment, destructive changes in the mucosa membrane were still present, but swelling of mucosa lamina propria and submucosa of the tracheal wall greatly decreased, probably due to evacuation of tissue fluid excess into the lumen. We can assume that changes in the structure of the tracheal wall in experimental hemorrhagic stroke impair the barrier function of the wall, which can contribute to the development of pneumonia, a serious inflammatory complications of stroke.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 4, pp. 467–469, April, 2011
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Klyueva, L.A. Morphological Changes in Rat Tracheal Wall in Experimental Hemorrhagic Stroke. Bull Exp Biol Med 151, 485–487 (2011). https://doi.org/10.1007/s10517-011-1363-3
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DOI: https://doi.org/10.1007/s10517-011-1363-3