The counts of dendritic cells and cytotoxic T-lymphocytes in the thymus decrease during its aging. The counts of dendritic cells decrease in senile age, while low counts of cytotoxic T-cells are observed only in long-living individuals. Presumably, reduction of the counts of thymic dendritic cells causes disorders in the differentiation of T-cells, particularly of cytotoxic ones, which can represent a mechanism of thymus involution during its aging.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 4, pp. 439–441, April, 2011
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Linkova, N.S., Polyakova, V.O. & Kvetnoy, I.M. Role of Dendritic Cells in the Formation of Subpopulation of Cytotoxic T-Lymphocytes in the Thymus during Its Aging. Bull Exp Biol Med 151, 457–459 (2011). https://doi.org/10.1007/s10517-011-1355-3
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DOI: https://doi.org/10.1007/s10517-011-1355-3