Effects of CYP1A2 Gene Polymorphisms on Antipyrine CYP1A2-Dependent Metabolism
- 67 Downloads
The distribution of two CYP1A2 gene polymorphisms, CYP1A2*F and CYP1A2*D, was studied in a group of 38 men. Antipyrine elimination test was carried out and urinary cotinine was measured. The contribution of these CYP1A2 gene polymorphisms, age, and tobacco smoking to accumulation of three main antipyrine metabolites in the urine was evaluated by regression analysis. The impact of both studied polymorphisms was essential for urinary levels of 3-hydroxymethylantipyrine (metabolite most dependent on cytochrome P-4501A2) and hence, for functional activity of this isoform of the enzyme.
Key Wordsgenetic polymorphism cytochrome P-4501A2 metabolism antipyrine cotinine
- 2.V. A. Ostashevskii, K. E. Gerasimov, I. B. Tsyrlov, and V. S. Rumak, Izv. Rossiisk. Akad. Nauk, Ser. Biology, No. 1, 56–62 (1994).Google Scholar
- 3.I. A. Rakhmanov, A. V. Semenyuk, N. M. Slyn’ko, et al., Khim. Farm. Zh., No. 3, 351–354 (1989).Google Scholar
- 4.Yu. I. Chernyak, J. A. Grassman, and S. I. Kolesnikov, The Impact of Persistent Organic Pollutants Exposure on Xenobiotics Biotransformation [in Russian], Novosibirsk (2007).Google Scholar