Tripeptide Pro-Gly-Pro interacted with dopamine receptors in vitro and reduced behavioral manifestations of apomorphine-induced hyperfunction of the dopamine system in verticalization, stereotypy, and yawning tests. Presumably, the behavioral effects of Pro-Gly-Pro tripeptide were mediated through post- and presynaptic D2 and D3 receptors.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 151, No. 4, pp. 410–413, April, 2011
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Meshavkin, V.K., Batishcheva, E.Y., Kost, N.V. et al. Effects of Pro-Gly-Pro Tripeptide on the Dopamine System. Bull Exp Biol Med 151, 429–431 (2011). https://doi.org/10.1007/s10517-011-1348-2
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DOI: https://doi.org/10.1007/s10517-011-1348-2