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Role of Stromal and Thy 1,2+ Cells in the Mechanisms of Action of Immobilized Granulocyte Colony-Stimulating Factor during Cytostatic-Induced Myelosuppression

  • Pharmacology and Toxicology
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Bulletin of Experimental Biology and Medicine Aims and scope

The effects of immobilized granulocyte colony-stimulating factor (mediated by cells of the hemopoiesis-inducing microenvironment) on hemopoietic precursors of various classes were studied on the model of cytostatic-induced myelosuppression (administration of cyclophosphamide). The action of this preparation was compared with that of the standard preparation of granulocyte colony-stimulating factor. Thy 1,2+ cells potentiated the effects of immobilized and standard granulocyte colony-stimulating factors on granulocyte-erythroid-macrophagemegakaryocyte precursors. Stromal cells were shown to potentiate the influence of these agents on granulocyte precursors. Induction of proliferation of precursor cells by the immobilized factor mediated by cells of the hemopoiesis-inducing microenvironment persisted for a longer period compared to that induced by the standard product.

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    T. V. Andreeva, O. V. Pershina, E. G. Skurikhin, E. S. Khmelevskaya & A. M. Dygai

  2. Scientific Futures Management Company, Novosibirsk, Russia

    A. V. Artamonov, A. A. Bekarev, E. I. Vereschagin & P. G. Madonov

Authors
  1. T. V. Andreeva
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  2. A. V. Artamonov
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  3. A. A. Bekarev
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  4. E. I. Vereschagin
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  5. P. G. Madonov
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  6. O. V. Pershina
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  7. E. G. Skurikhin
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  8. E. S. Khmelevskaya
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  9. A. M. Dygai
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Corresponding author

Correspondence to A. V. Artamonov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 523–528, November, 2010

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Andreeva, T.V., Artamonov, A.V., Bekarev, A.A. et al. Role of Stromal and Thy 1,2+ Cells in the Mechanisms of Action of Immobilized Granulocyte Colony-Stimulating Factor during Cytostatic-Induced Myelosuppression. Bull Exp Biol Med 150, 594–598 (2011). https://doi.org/10.1007/s10517-011-1199-x

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  • DOI: https://doi.org/10.1007/s10517-011-1199-x

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