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Perinatal Hypoxic-Ischemic Brain Injury Affects the Glutamatergic Signal Transduction Coupled with Neuronal ADP-Ribosyl Cyclase Activity

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

Agonists of glutamate ionotropic (NMDA) and metabotropic receptors (mGluRI and mGluRIII) had the regulatory effect on ADP-ribosyl cyclase/CD38 activity in cerebellar granular cells of newborn rats. Perinatal hypoxic-ischemic brain injury was followed by dysregulation of this mechanism.

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Authors and Affiliations

  1. Department of Biochemistry with the Course of Medical, Pharmaceutical, and Toxicological Chemistry, Krasnoyarsk, Russia

    A. B. Salmina, O. S. Okuneva, S. V. Mikhutkina, N. A. Malinovskaya, G. V. Yudin, D. V. Laletin, M. A. Fursov, O. V. Frolova, G. A. Tagaeva & E. V. Bolshakova

  2. Institute of Molecular Medicine and Pathobiochemistry, Krasnoyarsk, Russia

    A. B. Salmina, O. S. Okuneva, S. V. Mikhutkina, N. A. Malinovskaya, A. V. Morgun & E. V. Bolshakova

  3. P. G. Podzolkov Department of Pathological Anatomy, V. F. Voino-Yasenetskii Krasnoyarsk State Medical Academy, Federal Agency of Health and Social Development, Krasnoyarsk, Russia

    L. D. Zykova

Authors
  1. A. B. Salmina
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  2. O. S. Okuneva
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  3. S. V. Mikhutkina
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  4. N. A. Malinovskaya
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  5. A. V. Morgun
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  6. L. D. Zykova
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  7. G. V. Yudin
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  8. D. V. Laletin
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  9. M. A. Fursov
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  10. O. V. Frolova
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  11. G. A. Tagaeva
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  12. E. V. Bolshakova
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Corresponding author

Correspondence to A. B. Salmina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 11, pp. 511–515, November, 2010

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Salmina, A.B., Okuneva, O.S., Mikhutkina, S.V. et al. Perinatal Hypoxic-Ischemic Brain Injury Affects the Glutamatergic Signal Transduction Coupled with Neuronal ADP-Ribosyl Cyclase Activity. Bull Exp Biol Med 150, 583–586 (2011). https://doi.org/10.1007/s10517-011-1196-0

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  • DOI: https://doi.org/10.1007/s10517-011-1196-0

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