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Mechanisms of Hepatoprotective Effect of Immobilized Granulocyte colony-Stimulating Factor

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

The effect of immobilized granulocyte CSF on morphological characteristics and functional state of the liver was studied during chronic toxic hepatitis. The mechanisms of the therapeutic action of this agent were evaluated. The product had a strong hepatoprotective effect and exhibited the antiinflammatory and antisclerotic properties. The mechanism of activation of reserve systems for cell renewal (involved in restoration of the liver tissue) is probably related to an increase in proliferative activity of early precursor cells in the bone marrow, mobilization of these cells into the peripheral circulation, and directed homing into the liver tissue where they activate local regenerative mechanisms and prevent hepatocyte destruction. It should be emphasized that the concentration of SDF-1 increases in the liver tissue, but decreases in the bone marrow. These changes create the concentration gradient, which determines the migration of undifferentiated precursor cells to the liver.

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References

  1. G. G. Avtandilov, Medical Morphometry [in Russian], Moscow (1990).

  2. E. D. Gol’dberg, A. M. Dygai, V. V. Zhdanov, et al., Byull. Eksp. Biol. Med., Suppl. 1, 5–13 (2007).

  3. E. D. Gol’dberg, A. M. Dygai, V. V. Zhdanov, et al., Klet. Tekhnol. Biol. Med., No. 3, 123–126 (2006).

  4. E. D. Gol’dberg, A. M. Dygai, and V. P. Shakhov, Tissue Culture Methods in Hematology [in Russian], Tomsk (1992).

  5. A. M. Dygai, V. V. Zhdanov, O. I. Epshtein, et al., Klet. Tekhnol. Biol. Med., No. 1, 26–29 (2007).

  6. M. Hamidi, A. Azadi, and P. Rafiei, Drug Deliv., 13, No. 6, 399–409 (2006).

    Article  PubMed  CAS  Google Scholar 

  7. P. S. In’t Anker, W. A. Noort, S. A. Scherjon, et al., Haematologica, 88, No. 8, 845–852 (2003).

    PubMed  Google Scholar 

  8. T. Nakayama, N. Mutsuga, and G. Tosato, J. Natl. Cancer Inst., 99, No. 3, 223–235 (2007).

    Article  PubMed  CAS  Google Scholar 

  9. D. M. Piedmonte and M. J. Treuheit, Adv. Drug Deliv. Rev., 60, No. 1, 50–58 (2008).

    Article  PubMed  CAS  Google Scholar 

  10. Y. Tan, H. Shao, D. Eton, et al., Cardiovasc. Res., 73, No. 4, 823–832 (2007).

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia

    A. M. Dygai, V. V. Zhdanov, G. N. Zyuz’kov, L. A. Stavrova, E. V. Simanina, E. V. Udut, T. Yu. Khrichkova, L. A. Miroshnichenko, T. I. Fomina, T. V. Vetoshkina, T. Yu. Dubskaya & L. A. Ermolaeva

  2. Scientific Features Management Company, Tomsk, Russia

    E. I. Vereshchagin, P. G. Madonov & D. N. Kinsht

Authors
  1. A. M. Dygai
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  2. V. V. Zhdanov
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  3. G. N. Zyuz’kov
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  4. L. A. Stavrova
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  5. E. V. Simanina
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  6. E. V. Udut
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  7. T. Yu. Khrichkova
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  8. L. A. Miroshnichenko
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  9. E. I. Vereshchagin
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  10. P. G. Madonov
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  11. D. N. Kinsht
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  12. T. I. Fomina
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  13. T. V. Vetoshkina
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  14. T. Yu. Dubskaya
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  15. L. A. Ermolaeva
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Corresponding author

Correspondence to A. M. Dygai.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 10, pp. 371–375.

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Dygai, A.M., Zhdanov, V.V., Zyuz’kov, G.N. et al. Mechanisms of Hepatoprotective Effect of Immobilized Granulocyte colony-Stimulating Factor. Bull Exp Biol Med 150, 401–405 (2011). https://doi.org/10.1007/s10517-011-1152-z

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  • DOI: https://doi.org/10.1007/s10517-011-1152-z

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