Mechanisms of Protective Effect of Dicarbamin on the Blood System in Cytostatic Treatment

The effect of Dicarbamin preparation on hemopoiesis suppressed with cyclophosphamide was studied in animal experiments. It was shown that Dicarbamin produced a protective effect on granulocytic hemopoietic steam. This property of the preparation is determined by both protection of immature granulocytic cells at early terms after cytostatic treatment and more active maturation of neutrophils in the bone marrow due to enhanced secretion of humoral factors by elements of hemopoietic environment at late terms of the experiment.

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Correspondence to V. V. Zhdanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 9, pp. 312–316, September, 2010

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Nebolsin, V.E., Zhdanov, V.V., Zyuzkov, G.N. et al. Mechanisms of Protective Effect of Dicarbamin on the Blood System in Cytostatic Treatment. Bull Exp Biol Med 150, 343–347 (2011). https://doi.org/10.1007/s10517-011-1138-x

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Key Words

  • Dicarbamin
  • granulocytopoiesis
  • granulocytic precursors
  • cytostatic myelosuppression