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Insulin-Like Growth Factor-1 and Insulin Inhibit Caspase-3/7 Activation Initiated by Interleukin-1β in the Rat Eye Retinal Neurons

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Proinflammatory cytokine IL-1β specifically stimulates caspase-3/7 in vitro in RGC-5 rat eye retinal neurons. Insulin and insulin-like growth factor-1 and their combination inhibit caspase-3/7 activation in these cells, induced by removal of the serum from culture medium and/or by IL-1β treatment.

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Authors and Affiliations

  1. Institute of Carcinogenesis, N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia

    S. S. Shushanov

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  1. S. S. Shushanov
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Correspondence to S. S. Shushanov.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 150, No. 7, pp. 48–50, July, 2010

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Shushanov, S.S. Insulin-Like Growth Factor-1 and Insulin Inhibit Caspase-3/7 Activation Initiated by Interleukin-1β in the Rat Eye Retinal Neurons. Bull Exp Biol Med 150, 42–44 (2010). https://doi.org/10.1007/s10517-010-1063-4

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  • DOI: https://doi.org/10.1007/s10517-010-1063-4

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