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Hemorheological Effects of Ortho-Isobornyl Phenol Derivative under Conditions of Brain Ischemia in Rats

Bulletin of Experimental Biology and Medicine volume 149, pages 721–723 (2010)Cite this article

Hemorheological activity of 4-methyl-2,6-di-isobornyl phenol, a new o-isobornyl phenol derivative, was studied under conditions of experimental prolonged partial cerebral ischemia. Brain ischemia is associated with hemorheological disorders which can be characterized as blood hyperviscosity syndrome: increased viscosity of the whole blood (within a wide range of shear rates), plasma viscosity, fi brinogen content in blood plasma, and platelet aggregation; deterioration of platelet deformability and reduced availability of oxygen for tissues. A course (5 days) of intragastric 4-methyl-2,6-di-isobornyl phenol (100 mg/kg) prevented the development of blood hyperviscosity syndrome by modulating blood macrorheology (reduction of plasma viscosity and fi brinogen content) and microrheology (reduction of erythrocyte aggregation and improvement of their deformability).

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Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, the Russian Academy of Medical Sciences, Moscow, Russia

    M. B. Plotnikov, V. I. Smolyakova, I. S. Ivanov & G. A. Chernisheva

  2. Institute of Chemistry, Komi Research Center, the Ural Division of the Russian Academy of Sciences, Syktyvkar, Russia

    A. V. Kuchin & I. J. Chukicheva

  3. Siberian State Medical University, Tomsk, Russia

    E. A. Krasnov

Authors
  1. M. B. Plotnikov
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  2. V. I. Smolyakova
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  3. I. S. Ivanov
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  4. G. A. Chernisheva
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  5. A. V. Kuchin
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  6. I. J. Chukicheva
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  7. E. A. Krasnov
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Corresponding author

Correspondence to M. B. Plotnikov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 6, pp. 660-662, June, 2010

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Plotnikov, M.B., Smolyakova, V.I., Ivanov, I.S. et al. Hemorheological Effects of Ortho-Isobornyl Phenol Derivative under Conditions of Brain Ischemia in Rats. Bull Exp Biol Med 149, 721–723 (2010). https://doi.org/10.1007/s10517-010-1035-8

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  • DOI: https://doi.org/10.1007/s10517-010-1035-8

Key Words

  • brain ischemia
  • blood rheology
  • blood hyperviscosity syndrome
  • o-isobornyl phenol