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Hemostimulating Effects of Immobilized Hyaluronidase and Their Mechanisms during Cytostatic-Induced Myelosuppression

We studied the effect of immobilized hyaluronidase on hemopoiesis under conditions of cyclophosphamide-induced suppression. The preparation was shown to possess high hemostimulating activity. The stimulatory effect of hyaluronidase on the erithron was more pronounced than its effect on the granulocytic hemopoietic stem due to increase in functional activity of hemopoietic precursors and hemopoiesis-inducing microenvironment.

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Correspondence to A. M. Dygai.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 5, pp. 528-531, May, 2010

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Dygai, A.M., Artamonov, A.V., Bekarev, A.A. et al. Hemostimulating Effects of Immobilized Hyaluronidase and Their Mechanisms during Cytostatic-Induced Myelosuppression. Bull Exp Biol Med 149, 594–597 (2010). https://doi.org/10.1007/s10517-010-1001-5

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  • DOI: https://doi.org/10.1007/s10517-010-1001-5

Key Words

  • myelosuppression
  • immobilized hyaluronidase
  • erythropoiesis
  • granulocytopoiesis