Children patients with alterative-exudative (gastrointestinal diseases) and allergic inflammation (bronchial asthma) exhibited similar changes in fatty acide composition of erythrocyte and leukocyte membranes. They included accumulation of considerable amounts of eicosapentaenoic acid and decrease in the content of docosahexaenoic acid (long-chain derivative of eicosapentaenoic acid). The accumulation of eicosapentaenoic acid and decrease in the content of docosahexaenoic acid in cell membranes probably play a role in the pathogenesis of chronic inflammatory diseases. It is related to a possible decrease in the formation of antiinflammatory eicosanoids (series-5 leukotrienes) and protective compounds (resolvins and protectins) from fatty acids and changes in the physicochemical properties of cell membranes.
Similar content being viewed by others
References
O. N. Komarova, N. M. Shilina, N. N. Pogomii, et al., Pediatriya, No. 5, 35–42 (2006).
A. A. Pokrovskii, M. M. Levachev, and M. M. G. Gapparov, Vopr. Pitaniya, No. 4, 3–11 (1973).
Manual on the Control of the Quality and Safety of Biologically Active Food Additives [in Russian], Moscow (2004).
V. B. Spirichev, V. M. Kodentsova, O. A. Vrzhesinskaya, et al., Methods for the Evaluation of Vitamin Supply for People [in Russian], Moscow (2001).
V. N. Titov, Laboratory Diagnostics and Diet Therapy of Hyperlipoproteinemias (Biological Bases) [in Russian], Moscow (2006).
R. G. Coffey, J. W. Hadden, and E. Middleton, J. Clin. Invest., 54, 138–146 (1974).
M. Griese, N. Schur, M. D. Laryea, et al., Eur. J. Pediatr., 149, No. 7, 508–512 (1990).
S. B. Miller, Semin. Arthritis Rheum., 36, No. 1, 37–49 (2006).
R. C. Murphy and M. A. Gijon, Biochem. J., 405, No. 3, 379–395 (2007).
C. N. Serhan, Annu. Rev. Immunol., 25, 101–137 (2007).
R. Uauy and C. Castillo, J. Nutr., 133, 2962S–2972S (2003).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 5, pp. 516-519, May, 2010
Rights and permissions
About this article
Cite this article
Shilina, N.M., Komarova, O.N., Medvedev, F.A. et al. Accumulation of Eicosapentaenoic Acid in Membranes of Erythrocytes and Leukocytes during Alterative-Exudative and Allergic Inflammation. Bull Exp Biol Med 149, 583–586 (2010). https://doi.org/10.1007/s10517-010-0998-9
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10517-010-0998-9