We studied the dose-dependent effect of antibodies to glutamate on the stress response in C57Bl/6 mice. The antibodies were administered immediately after stress exposure. Intranasal administration of antibodies to glutamate in doses of 150 and 250 μg/kg immediately after stress exposure was shown to reduce the stress response under conditions of combined restraint stress. This effect was most pronounced after treatment with antibodies in a dose of 250 μg/kg: we revealed a decrease in the number and severity of erosive and ulcerative lesions in the gastric mucosa, i.e. anti-glutamate antibodies have a protective effect.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 5, pp. 484-486, May, 2010
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Evseev, V.A., Vetrile, L.A. & Zaharova, I.A. Effect of Intranasal Administration of Anti-Glutamate Antibodies after Stress Exposure on the Stress Response. Bull Exp Biol Med 149, 551–553 (2010). https://doi.org/10.1007/s10517-010-0990-4
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DOI: https://doi.org/10.1007/s10517-010-0990-4