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Experimental Evaluation of Rat Cord Blood as a Source of Stem Cells Stimulating Regeneration of the Bone Tissue

  • Translated from Kletochnye Tekhnologii v Biologii i Meditsine (Cell Technologies in Biology and Medicine)
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

We studied subpopulation structure of rat cord blood and its effects on regeneration of the bone tissue. In cord blood leukocytes, cell fractions with phenotypes CD45+/CD90−, CD45−/CD90+, CD34+/CD45+ were determined. The cells adhered to plastic during culturing and had a fibroblast-like morphology. Transplantation of rat cord blood cells into modeled femoral bone defects stimulated regeneration of the bone tissue and led to recovery of its anatomical integrity, which was confirmed by X-ray examination and histological analysis. No complete recovery of the bone structure was observed in controls (without cell implantation).

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Authors and Affiliations

  1. Bashkir State Medical University, Ufa, Russia

    A. V. Melnikova, A. G. Khasanov & A. I. Sendik

  2. Institute of Biochemistry and Genetics, Ufa Research Center of the Russian Academy of Sciences, Ufa, Russia

    S. V. Sibiryak

Authors
  1. A. V. Melnikova
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  2. A. G. Khasanov
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  3. A. I. Sendik
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  4. S. V. Sibiryak
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Corresponding author

Correspondence to A. V. Melnikova.

Additional information

Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 2, pp. 68–71, April, 2010

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Melnikova, A.V., Khasanov, A.G., Sendik, A.I. et al. Experimental Evaluation of Rat Cord Blood as a Source of Stem Cells Stimulating Regeneration of the Bone Tissue. Bull Exp Biol Med 149, 502–504 (2010). https://doi.org/10.1007/s10517-010-0979-z

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  • DOI: https://doi.org/10.1007/s10517-010-0979-z

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