Adaptation to short-term stress exposures prevents immobilization stress-induced decrease in functional activity of BKCa channels in smooth muscle cells of coronary vessels developing against the background of NO overproduction and increase in the relative content of oxidized glutathione (change in redox state of the glutathione system). The protective antistress mechanisms of adaptation probably include prevention of NO overproduction by inducible NO synthase and maintenance of dependent glutathione redox state functional activity of BKCa channels in smooth muscle cells of coronary vessels.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 4, pp. 372–378, April, 2010
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Solodkov, A.P., Maiorova, S.S. & Lazuko, S.S. Adaptation to Short-Term Stress Exposures Prevents Poststress Dysfunction of Calcium-Activated Potassium Channels in Coronary Vessels. Bull Exp Biol Med 149, 391–396 (2010). https://doi.org/10.1007/s10517-010-0953-9
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DOI: https://doi.org/10.1007/s10517-010-0953-9