The endothelium-dependent and myogenic reactions of pia mater arteries of the 1st-5th branching orders were studied in 1-, 3-, and 24-month-old rats by biomicroscopy method. The endothelium-independent (myogenic) reaction predominated in the 1st-3rd order branches and the endothelium-dependent vascular reaction in the 5th order branches of 3-month-old rats. Both regulatory mechanisms were equally developed in the 4th order branches. In 1-monthold rats, the endothelium-dependent reaction was more active in the majority of branches. In 24-month-old rats, this reaction was significantly higher than the endothelium-independent one only in the 4th and 5th order branches. In contrast to 3-month-old rats, the myogenic reaction of 24-month-old animals predominated in the 1st and 2nd order branches and the endotheliumdependent one in the 4th and 5th order branches. Vascular reactivity of 24-month-old rats was lower than in younger rats in all cases.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 3, pp. 340-344, March, 2010
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Chertok, V.M., Kotsyuba, A.E. Age-Associated Characteristics of Vasomotor Regulation of the Pia Mater Arteries in Rats. Bull Exp Biol Med 149, 364–368 (2010). https://doi.org/10.1007/s10517-010-0947-7
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DOI: https://doi.org/10.1007/s10517-010-0947-7