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Antioxidant System and Energy Provision of the Rat Heart during Aging Depend on Illumination Regimen and Are Resistant to Exogenous Melatonin

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Activities of antioxidant enzymes, vitamin E level, lactate dehydrogenase isoenzyme spectrum, and effects of melatonin on these parameters were studied in the myocardium of rats aged 6, 12, 18, and 24 months exposed to different illumination regimens. The greatest number of changes was recorded in rats exposed to permanent illumination and light deprivation. Activity of SOD decreased with age, while catalase activity increased. Melatonin treatment did not modify activities of antioxidant enzymes and negligibly modified the level of tocopherol and isoenzyme spectrum of lactate dehydrogenase in rat heart.

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Authors and Affiliations

  1. Institute of Biology, Karelian Research Center, Russian Academy of Sciences, Petrozavodsk, Russia

    E. A. Khizhkin, V. A. Ilukha, T. N. Ilyina & A. R. Unzhakov

  2. Petrozavodsk State University, Petrozavodsk, Russia

    I. A. Vinogradova

  3. N. N. Petrov Institute of Oncology, Federal Agency for High-Technological Medical Care, St. Petersburg, Russia

    V. N. Anisimov

Authors
  1. E. A. Khizhkin
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  2. V. A. Ilukha
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  3. T. N. Ilyina
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  4. A. R. Unzhakov
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  5. I. A. Vinogradova
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  6. V. N. Anisimov
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Corresponding author

Correspondence to E. A. Khizhkin.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 3, pp. 330–343, March, 2010

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Khizhkin, E.A., Ilukha, V.A., Ilyina, T.N. et al. Antioxidant System and Energy Provision of the Rat Heart during Aging Depend on Illumination Regimen and Are Resistant to Exogenous Melatonin. Bull Exp Biol Med 149, 354–358 (2010). https://doi.org/10.1007/s10517-010-0945-9

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  • DOI: https://doi.org/10.1007/s10517-010-0945-9

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