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Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles

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Bulletin of Experimental Biology and Medicine Aims and scope

Antitumor activity of TNF-α incorporated in nanoparticles (VLP-TNF-α) and dynamics of its accumulation and elimination from the blood and tumor tissue were studied in ICR mice. The VLP-TNF-α preparation exhibited higher antitumor activity compared to free TNF-α, presumably due to longer circulation of the cytokine in the blood and its more intensive accumulation by tumor tissue.

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Authors and Affiliations

  1. Institute of Medical Biotechnology, Vector Center of Virology and Biotechnology, Novosibirsk Region, Berdsk, Russia

    S. G. Gamaley, A. V. Bateneva, G. M. Sysoeva, E. D. Danilenko, L. R. Lebedev & V. I. Masycheva

Authors
  1. S. G. Gamaley
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  2. A. V. Bateneva
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  3. G. M. Sysoeva
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  4. E. D. Danilenko
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  5. L. R. Lebedev
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  6. V. I. Masycheva
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Corresponding author

Correspondence to S. G. Gamaley.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 3, pp. 296-299, March, 2010

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Gamaley, S.G., Bateneva, A.V., Sysoeva, G.M. et al. Pharmacokinetics and Antitumor Effects of the Drug Containing TNF-α in Nanoparticles. Bull Exp Biol Med 149, 320–323 (2010). https://doi.org/10.1007/s10517-010-0937-9

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  • DOI: https://doi.org/10.1007/s10517-010-0937-9

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