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Effect of Antibodies to Glutamate on Retention of Conditioned Passive Avoidance Response in Rats with Ischemic Injury of the Prefrontal Cortex

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Bulletin of Experimental Biology and Medicine Aims and scope

Experiments were performed on rats with bilateral photothrombosis of vessels in the prefrontal cortex. Intranasal administration of antibodies to glutamate (1 h after ischemia of the brain cortex) improved retention of conditioned passive avoidance response, which was elicited before ischemic damage. The content of antibodies to glutamate in the serum of rats increased significantly on day 8 after bilateral photochemical thrombosis of vessels in the prefrontal cortex compared to that in the control.

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References

  1. J. Buresh, O. Bureshova, and J. P. Houston, Methods and Main Experiments for Studies of the Brain and Behavior [in Russian], Moscow (1991).

  2. E. I. Gusev and V. I. Skvortsova, Cerebral Ischemia [in Russian], Moscow (2001).

  3. T. V. Davydova, N. I. Voskresenskaya, V. G. Fomina, et al., Byull. Eksp. Biol. Med., 143, No. 2, 140-141 (2007).

    Article  Google Scholar 

  4. T. V. Davydova, N. I. Voskresenskaya, V. G. Fomina, et al., Ibid., 142, No. 12, 624-626 (2006).

    Google Scholar 

  5. V. A. Evseev, Antibodies to Neurotransmitters in the Mechanisms of Neuroimmunopathology [in Russian], Moscow (2007).

  6. G. A. Romanova, I. V. Barskov, R. U. Ostrovskaya, et al., Patol. Fiziol. Eksper. Ter., No. 2, 8-10 (1998).

    Google Scholar 

  7. G. A. Romanova, Dysregulation Pathology, Ed. G. N. Kryzhanovskii [in Russian], Moscow (2002), pp. 605-615.

  8. The Rat Brain in Stereotaxic Coordinates. 3rd Edition, G. Paxinos and C. Watson, San Diego (1997).

  9. P. Seguela, M. Geffard, R. Buijs, and M. Le Moal, Proc. Natl. Acad. Sci. USA, 81, No. 12, 3888-3892 (1984).

    Article  CAS  PubMed  Google Scholar 

  10. S. Talegaonkar and P. R. Mishra, Indian J. Pharmacol., 36, 140-147 (2004).

    CAS  Google Scholar 

  11. B. D. Watson, W. D. Dietrich, R. Busto, et al., Ann. Neurol., 17, No. 5, 497-504 (1985).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia

    G. A. Romanova, F. M. Shakova, V. Yu. Gorbatov, Yu. N. Kvashennikova & T. V. Davydova

Authors
  1. G. A. Romanova
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  2. F. M. Shakova
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  3. V. Yu. Gorbatov
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  4. Yu. N. Kvashennikova
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  5. T. V. Davydova
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Corresponding author

Correspondence to G. A. Romanova.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 3, pp. 261-264, March, 2010

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Romanova, G.A., Shakova, F.M., Gorbatov, V.Y. et al. Effect of Antibodies to Glutamate on Retention of Conditioned Passive Avoidance Response in Rats with Ischemic Injury of the Prefrontal Cortex. Bull Exp Biol Med 149, 289–292 (2010). https://doi.org/10.1007/s10517-010-0929-9

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  • DOI: https://doi.org/10.1007/s10517-010-0929-9

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