Morphofunctional evaluation of the effect of biological dressing with collagen-1 on healing of 3A degree burn wound in outbred and mutant Hr hrHrhr (hairless) mice was carried out by the histological method and optic radioautography. A pronounced stimulatory effect of the dressing on skin regeneration in mice was demonstrated. According to radioautography data, early dressing of the burn wounds in Hr hr hrmice led to active proliferation of epithelial cells in dermal cyst and vascular endotheliocytes. The possible mechanisms of the stimulatory effect of collagen-based dressing on wound healing are discussed.
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Translated from Kletochnye Tehnologii v Biologii i Medicine, No. 1, pp. 47-54, January, 2010
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Kolokolchikova, E.G., Zhirkova, E.A., Golovatenko-Abramov, P.K. et al. Morphofunctional Evaluation of the Effect of Collagen-1-Based Dressing on Skin Regeneration after Burn Trauma in Mice of Two Genetic Strains. Bull Exp Biol Med 149, 154–160 (2010). https://doi.org/10.1007/s10517-010-0896-1
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DOI: https://doi.org/10.1007/s10517-010-0896-1