We studied the effect of 5-HT1A receptor agonist buspirone on behavior of male C57Bl/6J mice in the “partition” test, which reflects communicativeness of animals. Single administration of buspirone (1 mg/kg) to intact mice and animals experienced defeats in 20 intermale confrontations impaired their communicativeness, especially in intact animals. On the contrary, administration of buspirone (1 mg/kg) to losers starting from day 5 of intermale confrontations for 2 weeks produced a positive effect and prevented impairment of communicativeness by day 20 of confrontations. The role of brain 5-HT1A receptors in these processes is discussed.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 64–68, January, 2010
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Avgustinovich, D.F., Vishnivetskaya, G.B. & Koryakina, L.A. Effect of Acute and Chronic Buspirone Administration on Communicativeness of Mice with Experience of Defeats in Social Conflicts. Bull Exp Biol Med 149, 57–61 (2010). https://doi.org/10.1007/s10517-010-0875-6
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DOI: https://doi.org/10.1007/s10517-010-0875-6