The dynamics of changes in serum proteome was studied under conditions of experimental 9-day seclusion in a pressure chamber at 5 m H2O pressure with modified gaseous environment. The proteomic profile for the molecular weight range of 1000-17,000 Da changed by 75%. Increased content of acute phase proteins (complement components, inter-α-trypsin inhibitor, and high-molecular-weight kininogen) was observed on day 1 of the experiment before the exposure. On day 9 of exposure, the peaks of AII, CI, and CII apolipoproteins decreased and angiotensin II peak increased.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 42–44, January, 2010
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Pakharukova, N.A., Pastushkova, L.K., Popova, Y.A. et al. Study of Normal Human Serum Proteomic Profile under Conditions of Hyperbaric Oxygen-Nitrogen-Argon Exposure. Bull Exp Biol Med 149, 37–39 (2010). https://doi.org/10.1007/s10517-010-0869-4
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DOI: https://doi.org/10.1007/s10517-010-0869-4