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Donepezil Eliminates Suppressive Effects of β-Amyloid Peptide (1-42) on Long-Term Potentiation in the Hippocampus

  • Biophysics and Biochemistry
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Bulletin of Experimental Biology and Medicine Aims and scope

β-Amyloid peptide 1-42 in a concentration of 200 nM impairs induction of long-term posttetanic potentiation of population spike in CA1 pyramidal neurons in rat hippocampal slices. Application of donepezil, a drug used for the treatment of Alzheimer disease, in a concentration of 1 μM eliminates the suppressive effect of β-amyloid peptide 1-42 on long-term posttenanic potentiation in the hippocampus.

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia

    N. A. Kapai, E. I. Solntseva & V. G. Skrebitskii

Authors
  1. N. A. Kapai
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  2. E. I. Solntseva
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  3. V. G. Skrebitskii
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Corresponding author

Correspondence to E. I. Solntseva.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 38–41, January, 2010

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Kapai, N.A., Solntseva, E.I. & Skrebitskii, V.G. Donepezil Eliminates Suppressive Effects of β-Amyloid Peptide (1-42) on Long-Term Potentiation in the Hippocampus. Bull Exp Biol Med 149, 33–36 (2010). https://doi.org/10.1007/s10517-010-0868-5

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  • DOI: https://doi.org/10.1007/s10517-010-0868-5

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