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Effect of Glyprolines on Homeostasis of Gastric Mucosa in Rats with Stress Ulcers

  • General Pathology and Pathophysiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Pro-Gly-Pro and its metabolite Gly-Pro effectively prevented the development of erosive and ulcerative lesions of the gastric mucosa in rats under conditions of water-immersion restraint stress by restoring the oxidatant-antioxidant balance in the total fraction of gastric mucosa cells. Pro-Gly was least effective in this respect. We conclude that glyprolines hold much promise as pharmaceutical products, which can be used in gastroenterological practice for the prevention and therapy of ulcer disease of the stomach and duodenum.

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Authors and Affiliations

  1. Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia

    G. E. Samonina

  2. Department of Pharmaceutical Physiology, Biological Faculty, T. G. Shevchenko Kiev National University, Moscow, Russia

    T. M. Falalyeyeva, T. V. Beregovaya & E. V. Dvorshchenko

  3. Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia

    L. A. Andreeva

Authors
  1. T. M. Falalyeyeva
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  2. G. E. Samonina
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  3. T. V. Beregovaya
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  4. L. A. Andreeva
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  5. E. V. Dvorshchenko
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Corresponding author

Correspondence to G. E. Samonina.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 30–33, January, 2010.

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Falalyeyeva, T.M., Samonina, G.E., Beregovaya, T.V. et al. Effect of Glyprolines on Homeostasis of Gastric Mucosa in Rats with Stress Ulcers. Bull Exp Biol Med 149, 26–28 (2010). https://doi.org/10.1007/s10517-010-0866-7

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  • DOI: https://doi.org/10.1007/s10517-010-0866-7

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