In patients with complicated essential hypertension (ischemic stroke) and coronary heart disease, inductors of platelet aggregation in various doses induced “paradoxical” changes in platelet aggregation activity reflecting the degree of decompensation under conditions of persistent endothelial dysfunction. Aggregation inductors in low doses were shown to have a greater diagnostic significance. The content of endothelial dysfunction markers in the blood was persistently elevated under these conditions.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 22–24, January, 2010
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Shimohina, N.Y., Petrova, M.M., Savchenko, A.A. et al. Platelet Aggregation and Endothelial Function in Patients with Complicated Essential Hypertension (Ischemic Stroke) and Coronary Heart Disease. Bull Exp Biol Med 149, 18–20 (2010). https://doi.org/10.1007/s10517-010-0864-9
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DOI: https://doi.org/10.1007/s10517-010-0864-9