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Heparin Inhibits Contraction of Smooth Muscle Cells in Lymphatic Vessels

  • Physiology
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Bulletin of Experimental Biology and Medicine Aims and scope

Heparin in concentrations of 10–50 U/ml produced a decrease in the amplitude and frequency of phasic contractions of smooth muscle cells of bovine mesenteric lymphatic vessels. Vascular wall tension was reduced under these conditions. The endothelium-dependent effect of heparin is realized via an increase in the production of nitric oxide by endothelial cells and, to a lesser degree, via the stimulation of prostacyclin synthesis.

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Authors and Affiliations

  1. Laboratory for Physiology of Blood Circulation, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia

    G. I. Lobov & M. N. Pan’kova

Authors
  1. G. I. Lobov
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  2. M. N. Pan’kova
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Correspondence to G. I. Lobov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 149, No. 1, pp. 7–10, January, 2010

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Lobov, G.I., Pan’kova, M.N. Heparin Inhibits Contraction of Smooth Muscle Cells in Lymphatic Vessels. Bull Exp Biol Med 149, 4–6 (2010). https://doi.org/10.1007/s10517-010-0860-0

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  • DOI: https://doi.org/10.1007/s10517-010-0860-0

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