Single administration of brain-derived neurotrophic factor (BDNF) into the lateral ventricle of ASC mice (Antidepressant Sensitive Catalepsy), a model of depression-like state, significantly decreased predisposition to cataleptic freezing in these animals. These findings indicate that BDNF can appear as a promising antidepressant of new generation and that ASC mice can be used as an adequate model for investigations of the mechanisms of behavior modification by BDNF.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 12, pp. 649-652, December, 2009
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Tikhonova, M.A., Kulikov, A.V., Naumenko, V.S. et al. Intracerebral Administration of Brain-Derived Neurotrophic Factor (BDNF) Reduces Severity of Cataleptic Freezing in Mice with Genetic Predisposition to Catalepsy. Bull Exp Biol Med 148, 889–891 (2009). https://doi.org/10.1007/s10517-010-0844-0
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DOI: https://doi.org/10.1007/s10517-010-0844-0