We studied the effect of interleukin-1β on the behavior of rats with different individual typological characteristics during mild stress in the open-field test. Intraperitoneal injection of interleukin-1β (5 μg/kg, 108 U/mg) was followed by a decrease in orientation and exploratory activity of passive and, particularly, of active animals in the open field. As differentiated from rats receiving physiological saline, the initial differences in behavioral characteristics of active and passive animals were not revealed in the repeated test after injection of interleukin-1β. We conclude that interleukin-1β abolishes the behavioral differences between active and passive specimens in the open field. These data suggest that administration of interleukin-1β to rats leads to reorganization of the mechanisms for emotional evaluation of adverse emotiogenic factors under conditions of mild stress in the open-field test.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 11, pp. 488–490, November, 2009
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Pertsov, S.S., Koplik, E.V., Simbirtsev, A.S. et al. Effect of Interleukin-1β on the Behavior of Rats during Mild Stress in the Open-Field Test. Bull Exp Biol Med 148, 735–737 (2009). https://doi.org/10.1007/s10517-010-0804-8
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DOI: https://doi.org/10.1007/s10517-010-0804-8