Effects of nonspecific opiate receptor antagonist naloxone in doses of 0.1, 0.5, 1.0, 5.0, 10.0 mg/kg on open field behavior and spontaneous motor activity were studied in male BALB/c and С57Bl/6 mice. Differently directed effects of naloxone on behavioral parameters of emotional-stress reaction in BALB/c and С57Bl/6 mice were observed. Naloxone increased motor activity in the open field test in BALB/c mice, but decreased it in С57Bl/6 mice. In the absence of stress, naloxone in the studied dose range did not affect spontaneous motor activity in С57Bl/6 mice, and significantly reduced activity in BALB/c mice in doses 0.5 and 1.0 mg/kg.
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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, No. 10, pp. 411-413, October, 2009
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Nadorova, A.V., Kozlovskaja, M.M. & Seredenin, S.B. Naloxone Effects on Behavior of Inbred Mice with Different Response to Emotional Stress in Open Field Test. Bull Exp Biol Med 148, 609–611 (2009). https://doi.org/10.1007/s10517-010-0776-8
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DOI: https://doi.org/10.1007/s10517-010-0776-8