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Preclinical Studie of General Toxic Properties of Preparations Containing Ultralow Doses of Antibodies to Endogenous Regulators

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Bulletin of Experimental Biology and Medicine Aims and scope

Preclinical study of the safety of 6 preparations containing ultralow doses of antibodies to endogenous regulators showed that they are relatively safe, are well tolerated by animals in doses more than 1000-fold surpassing the therapeutic dose for humans, and produce no general toxic effect on the organism of laboratory animals.

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References

  1. M. L. Belen’kii, Elements of Quantitative Evaluation of a Pharmacological Effect [in Russain], Leningrad (1963).

  2. E. B. Berkhin and Yu. I. Ivanov, Methods of Experimental Examination of the Kidneys and Water-Salt Metabolism [in Russian], Barnaul (1972).

  3. D. I. Goldberg, E. D. Goldberg, and N. G. Shubin, Hematology of Animals [in Russian], Tomsk (1973).

  4. V. G. Kolb and V. S. Kamyshnikov, Clinical Biochemistry [in Russian], Minsk (1982).

  5. Normal Parameters in Laboratory Animals in Toxicological Experiments [in Russian], Ed. I. M. Trakhtenberg et al., Moscow (1978).

  6. Manual on Experimental (Preclinical) Study of New Pharmacological Substances. Ed. R. U. Khabriev [in Russian], Moscow (2005).

  7. I. P. Ulanova, G. G. Avilova, and V. A Tutarikova, Methods of Evaluation of Toxicity and Hazard of Chemical Substances [in Russian], Moscow (1970).

  8. O. I. Epshtein, Neurophysiological Mechanisms of Pharmacological Effects of Potentiated (Homeopathized) Antibodies to Brain-Specifi c S-100 Protein. Author’s Synopsis of Cand. Med. Sci. Dissertation, Tomsk (1999).

  9. O. I. Epshtein, M. B. Shtark, A. M. Dygai, et al., Pharmacology of Ultralow Doses of Antibodies to Endogenous Regulators of Functions [in Russian], Moscow (2005).

  10. J. K. Brady and W. J. H.Nauta, J. Cell Physiol., 46, No. 3, 339-340 (1953).

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Authors and Affiliations

  1. Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia

    G. V. Karpova, T. I. Fomina, T. V. Vetoshkina, T. Yu. Dubskaya, O. L. Voronova, E. A. Timina, E. V. Abramova, L. A. Ermolaeva & A. V. Perova

Authors
  1. G. V. Karpova
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  2. T. I. Fomina
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  3. T. V. Vetoshkina
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  4. T. Yu. Dubskaya
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  5. O. L. Voronova
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  6. E. A. Timina
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  7. E. V. Abramova
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  8. L. A. Ermolaeva
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  9. A. V. Perova
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Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 148, Suppl. 1, pp. 184-186, September, 2009

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Karpova, G.V., Fomina, T.I., Vetoshkina, T.V. et al. Preclinical Studie of General Toxic Properties of Preparations Containing Ultralow Doses of Antibodies to Endogenous Regulators. Bull Exp Biol Med 148, 543–546 (2009). https://doi.org/10.1007/s10517-010-0760-3

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  • DOI: https://doi.org/10.1007/s10517-010-0760-3

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